TheC. elegansATG101 homolog EPG-9 directly interacts with EPG-1/Atg13 and is essential for autophagy
نویسندگان
چکیده
منابع مشابه
The C. elegans ATG101 homolog EPG-9 directly interacts with EPG-1/Atg13 and is essential for autophagy.
Autophagy is an evolutionarily conserved catabolic process that involves the engulfment of cytoplasmic contents in a closed double-membrane structure, called the autophagosome, and their subsequent delivery to the vacuole/lysosomes for degradation. Genetic screens in Saccharomyces cerevisiae have identified more than 30 autophagy-related (Atg) genes that are essential for autophagosome formatio...
متن کاملThe coiled-coil domain protein EPG-8 plays an essential role in the autophagy pathway in C. elegans.
Macroautophagy (hereafter referred to as autophagy) involves the formation of a closed, double membrane structure, called the autophagosome. Most of the Atg proteins that are essential for autophagosome formation are evolutionarily conserved between yeast and higher eukaryotes. The functions of some Atg proteins, however, are mediated by highly divergent proteins in mammalian cells. In this stu...
متن کاملUpdating the reading EPG
The Reading EPG[1, 2] (Electropalatograph) was developed in the Speech Research Laboratory at The University of Reading as a device to allow the number, shape and position of contacts between the tongue and the roof of the mouth to be measured and recorded. This device is used both as a research tool[3, 4] and in speech therapy as a bio-feedback device. The preferred equipment used by major spe...
متن کاملClique coloring B1-EPG graphs
We consider the problem of clique coloring, that is, coloring the vertices of a given graph such that no (maximal) clique of size at least two is monocolored. It is known that interval graphs are 2-clique colorable. In this paper we prove that B1-EPG graphs (edge intersection graphs of paths on a grid, where each path has at most one bend) are 4-clique colorable. Moreover, given a B1-EPG repres...
متن کاملepg-1 functions in autophagy-regulated processes and may encode a highly divergent Atg13 homolog in C. elegans.
Autophagy is an evolutionarily conserved intracellular catabolic system for degradation of long-lived proteins or damaged organelles. In this study, we have identified and characterized a new gene, epg-1, that plays a role in the autophagy pathway in C. elegans. Loss of function of epg-1 causes defects in various autophagy-regulated processes, including degradation of aggregate-prone proteins a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Autophagy
سال: 2012
ISSN: 1554-8627,1554-8635
DOI: 10.4161/auto.21163